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2 679 635

(13)

(51)

IPC

G01N33/50(2006-01-01)

C12Q1/68(2006-01-01)

(21) (22)

Application

2018129783, 2018-08-15

(24)

Start date

2018-08-15

(22)

Actual filing date

2018-08-15

(45)

Published

2019-02-12

(72)

Inventor

Churnosov Mikhail IvanovichMoskalenko Mariya IvanovnaMilanova Snezhana NikolovnaPonomarenko Irina VasilevnaPolonikov Aleksej Valerevich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR PREDICTING THE RISK OF DEVELOPING AN ISCHEMIC STROKE, TAKING INTO ACCOUNT GENETIC AND MEDIUM FACTORS Russian patent published in 2019 - IPC G01N33/50 C12Q1/68

Abstract RU 2679635 C1

FIELD: medicine.

SUBSTANCE: invention relates to medical diagnostics and is intended to predict the risk of developing ischemic stroke. DNA is extracted from venous blood in Russian individuals who are natives of Central Chernozem Region, and polymorphisms of cytokine genes rs1061624 TNFR2 and rs767455 TNFR1 are analyzed. Identify smoking status. A high risk of ischemic stroke is predicted when a combination of genotype GG rs767455 TNFR1 with genotype GG rs1061624 TNFR2 and with a positive smoking status is detected.

EFFECT: invention ensures obtaining new criteria for assessing the risk of developing ischemic stroke based on data on combinations of genetic variants of loci of rs1061624 TNFR2, rs767455 TNFR1 and smoking status.

1 cl, 3 dwg, 3 ex

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RU 2 679 635 C1

Authors

Churnosov Mikhail Ivanovich

Moskalenko Mariya Ivanovna

Milanova Snezhana Nikolovna

Ponomarenko Irina Vasilevna

Polonikov Aleksej Valerevich

Dates

2019-02-12—Published

2018-08-15—Filed