PHARMACEUTICAL COMPOSITION INCLUDING 5-{4-(AMINOSULFONYL)PHENYL}-2,2-DIMETHYL-4-(3-FLUOROPHENYL)-3(2H)-FURANONE AND CAPSULE FORMULATION INCLUDING PHARMACEUTICAL COMPOSITION Russian patent published in 2019 - IPC A61K31/341 A61K47/38 A61K47/26 A61K47/12 A61K47/02 A61K9/48 A61P29/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: present invention relates to an anti-inflammatory pharmaceutical composition comprising 5-{4-(aminosulfonyl)phenyl}-2,2-dimethyl-4-(3-fluorophenyl)-3(2H)-furanone in crystalline form A, crystalline form G, or as a mixture of said crystalline forms, pharmaceutically acceptable diluent and pharmaceutically acceptable lubricant. Said active substance has a particle diameter of 50 % by volume (d_(0.5)) from 3 to 9 microns. Diluent is selected from a group consisting of silicified microcrystalline cellulose, microcrystalline cellulose, cellulose, lactose, and combinations thereof, and the lubricant is talc or stearic acid. Pharmaceutical composition according to the present invention has advantages due to good stability, high dissolution rate, improved uniformity, as well as satisfactory pharmacokinetic properties.

EFFECT: due to these advantages, the pharmaceutical composition according to the present invention is effective in treating inflammation or pain.

8 cl, 10 dwg, 11 tbl, 11 ex