FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, specifically to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure, in particular congestive heart failure, chronic kidney disease, advanced stage kidney disease, liver disease, and fluid retention caused by a peroxisome proliferator-activated gamma receptor agonist (PPAR). Invention also relates to compounds and methods for the treatment of hypertension, for the treatment of diseases of the gastrointestinal tract, including the treatment or reduction of pain associated with gastrointestinal diseases.
EFFECT: compounds are not absorbed and are not systemically bioavailable.
11 cl, 9 tbl, 79 ex
| Title |
Year |
Author |
Number |
| PHENYLTETRAHYDROISOQUINOLINE COMPOUND, SUBSTITUTED WITH HETEROARYL |
2015 |
- Kuroda, Shoichi
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- Ushiki, Yasunobu
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- Tabuse, Hideaki
- Munemoto, Eiji
- Chonan, Sumi
|
RU2703456C2 |
| DERIVATIVES OF TETRAHYDROISOQUINOLINE, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, METHOD FOR INHIBITION OF SYNAPTIC UPTAKE OF DOPAMINE AND TREATMENT METHOD |
2000 |
- Bek Dzhejms P.
- Smit Mark A.
|
RU2293728C2 |
| SUBSTITUTED 4-PHENYLTETRAHYDROISOQUINOLINES, PREPARATION METHOD, APPLICATION AS MEDICINAL AGENTS, AND ALSO MEDICINAL AGENTS CONTAINING THEM |
2005 |
- Khajnel'T Uve
- Lang Khans-Jokhen
- Virt Klaus
- Likher Tomas
- Khofmajster Armin
|
RU2398766C2 |
| NOVEL HETEROCYCLIC DERIVATIVES AND THEIR MEDICINAL USING |
2002 |
- Matsui Khirosi
- Kobajasi Khideo
- Azukizava Satoru
- Kasaj Masajasu
- Josimi Akikhisa
- Sirakhase Khiroaki
|
RU2287529C2 |
| SUBSTITUTED 4-PHENYLTETRAHYDROISOQUINOLINES, METHOD OF THEIR OBTAINING, THEIR APPLICATION AS MEDICATIONS, AND MEDICATIONS CONTAINING THEM |
2004 |
- Khofmajster Armin
- Khajnel'T Uve
- Lang Khans-Jokhen
- Frik Vendelin
- Bljajkh Markus
- Virt Klaus
|
RU2343147C2 |
| SUBSTITUTED TETRAHYDROISOQUINOLINE DERIVATIVE AS POSITIVE ALLOSTERIC MODULATOR D1 |
2020 |
|
RU2824581C2 |
| DERIVATIVES OF 4-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE-1-YL-UREA AND THEIR USE IN TREATMENT, INTER ALIA, DISEASES OF RESPIRATORY TRACT |
2011 |
- Finch Harry
- Van Niel Monique Bodil
- Woo Chi-Kit
|
RU2586333C1 |
| SUBSTITUTED PYRAZOLES, PHARMACEUTICAL COMPOSITION BASED ON SAID, METHOD OF PATIENT TREATMENT, INTERMEDIATE COMPOUND |
1993 |
- Dzhen M.Brajt
- Uillard M.Uehlch
|
RU2130453C1 |
| DERIVATIVES OF TETRAHYDROISOQUINOLINE AND THEIR SALTS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
2000 |
- Matsui Khirosi
- Kobajasi Khideo
- Azukizava Satoru
- Kasai Masajasu
- Josimi Akikhisa
- Sirakhase Khiroaki
|
RU2256661C2 |
| KINASE INHIBITORS |
2012 |
- Van Niel Monique Bodil
- Ray Nicholas Charles
- Alcaraz Lilian
- Panchal Terry Aaron
- Jennings Andrew Stephen Robert
- Armani Elisabetta
- Cridland Andrew Peter
- Hurley Christopher
|
RU2623734C9 |
