METHODS FOR TREATMENT OF LUNG DISORDERS Russian patent published in 2022 - IPC A61K31/337 A61K9/10 A61K9/14 A61P11/00 A61P35/00 

FIELD: medicine; oncology.

SUBSTANCE: group of inventions relates to medicine, namely to oncology, in particular to a method for the treatment of lung tumor using taxan particles. The method includes intrapulmonary administration to a subject with lung cancer by means of nebulizer of the effective amount of a composition in the form of a suspension, containing taxan particles and a pharmaceutically acceptable carrier. Taxan includes paclitaxel or its pharmaceutically acceptable salt. Taxan particles contain at least 95% of taxan, have an average size (quantitative) from 0.4 mcm to 3 mcm, specific surface area (SSA) from 27 m²/g to 60 m²/g. The suspension is converted to aerosol for the administration. Formed aerosol drops have a mass median aerodynamic diameter (MMAD) from 0.5 mcm to 6 mcm. The use of a composition containing taxan particles for the treatment of lung tumor is also proposed.

EFFECT: inventions lead to significantly more long-lasting retention of taxan in the lungs, in particular long-lasting period of action is at least 4 weeks.

21 cl, 54 dwg, 15 tbl, 4 ex