FIELD: medicine; pharmaceuticals.
SUBSTANCE: group of inventions relates to pharmaceutics. First invention represents a conjugate ligand-cytotoxic drug with structure formula
.
EFFECT: group of inventions includes a method for producing said conjugate, comprising a pharmaceutical composition thereof, use of said conjugate or composition for preparing a medicament for treating cancer, a method for modulating a receptor in vitro and a method of treating cancer.
32 cl, 12 ex, 4 tbl, 2 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| LIGAND CONJUGATE WITH CYTOTOXIC DRUG PREPARATION, METHOD AND APPLICATION THEREOF | 2016 |
|
RU2708461C2 |
| LIGAND-DRUG CONJUGATE OF EXATECAN ANALOGUE, ITS PRODUCTION METHOD AND ITS USE | 2019 |
|
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| ANTIBODY TO B7H3-EXATECAN ANALOGUE CONJUGATE AND ITS USE IN MEDICINE | 2019 |
|
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| ERIBULIN DERIVATIVE DRUG CONJUGATE, METHOD FOR PREPARATION THEREOF AND USE THEREOF IN MEDICINE | 2021 |
|
RU2830242C1 |
| CONJUGATE OF ANTI-CLAUDIN ANTIBODY AND MEDICINAL AGENT AND PHARMACEUTICAL USE THEREOF | 2020 |
|
RU2826119C1 |
| CONJUGATE OF TROP-2 ANTIBODY AND EXATECAN ANALOGUE AND MEDICAL USE THEREOF | 2021 |
|
RU2830167C1 |
| ANTI-B7-H4 ANTIBODY AND DRUG CONJUGATE AND MEDICAL USE THEREOF | 2020 |
|
RU2827531C2 |
| DERIVATIVES OF PYRROLOPYRIMIDINE USEFUL AS JAK-KINASES INHIBITORS | 2012 |
|
RU2618673C2 |
| PYRAZOLOPYRIMIDONE OR PYRROLOTRIAZONE DERIVATIVES, METHOD OF PREPARING SAME AND PHARMACEUTICAL APPLICATIONS THEREOF | 2014 |
|
RU2674977C2 |
| PYRIDYL KETONE DERIVATIVES, METHOD OF PREPARING SAME AND PHARMACEUTICAL APPLICATION THEREOF | 2014 |
|
RU2667892C2 |
