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2 685 947

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IPC

C12N1/21(2006-01-01)

(21) (22)

Application

2016152829, 2016-12-30

(24)

Start date

2016-12-30

(22)

Actual filing date

2016-12-30

(45)

Published

2019-04-23

(72)

Inventor

Suvorov Aleksandr NikolaevichChereshnev Valerij AleksandrovichSuvorova Mariya AleksandrovnaDuplik Nadezhda VladlenovnaKiseleva Ekaterina ProkhorovnaGryaznova Diana VasilevnaTsapieva Anna Nikolaevna

(73)

Holder

Suvorov Aleksandr Nikolaevich

RECOMBINANT STREPTOCOCCUS PYOGENES (pT7ErmEMM) STRAIN - TUMOR GROWTH INHIBITOR Russian patent published in 2019 - IPC C12N1/21

Abstract RU 2685947 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology. Disclosed is a recombinant strain of bacteria Streptococcus pyogenes M39 "Gurov", obtained by transforming the Streptococcus pyogenes "Gurov" strain with plasmid pT7ErmEMM, obtained based on the vector p7ermB by embedding on the HindIII and EcoRI sites of the emm gene fragment. Disclosed recombinant strain exhibits marked anti-tumor activity towards hepatoma and sarcoma tumors.

EFFECT: invention increases anti-tumor activity, reduces pathogenicity and improves survival rate of recombinant strain Streptococcus pyogenes and can be used in therapy of malignant growths.

1 cl, 3 dwg

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RU 2 685 947 C2

Authors

Suvorov Aleksandr Nikolaevich

Chereshnev Valerij Aleksandrovich

Suvorova Mariya Aleksandrovna

Duplik Nadezhda Vladlenovna

Kiseleva Ekaterina Prokhorovna

Gryaznova Diana Vasilevna

Tsapieva Anna Nikolaevna

Dates

2019-04-23—Published

2016-12-30—Filed