CROSS-LINKED HYALURONIC ACID, METHOD OF ITS PRODUCTION AND APPLICATION IN AESTHETIC SPHERE Russian patent published in 2019 - IPC A61K8/73 A61K8/42 A61L27/20 A61Q19/08 C08B37/08 

FIELD: cosmetology.

SUBSTANCE: group of inventions relates to aesthetic cosmetology, in particular to a method of producing a biocompatible cross-linked biopolymer, which is hyaluronic acid cross-linked using urea as a cross-coupling agent, according to which: a) dissolving hyaluronic acid or salt thereof in water or in physiological saline; b) dissolving urea in an aqueous solution of an acid; c) mixing solutions with steps a) and b) to obtain a solution having pH from 3 to 6.8, to provide cross-linking hyaluronic acid. In addition, disclosed are versions of using the obtained biopolymer as a dermal filler for increasing tissue volume in order to improve the aesthetic appearance of an anatomical feature of the subject or to assist in preventing aging, as well as a biopolymer filler and a cosmetic method for increasing tissue volume in a subject using said biopolymer.

EFFECT: group of inventions provides a biopolymer compatible with skin tissue and having proper filling properties for use as a dermal filler.

15 cl, 10 dwg, 5 ex