METHOD OF PREDICTING HEMATOGENOUS METASTASIS OF COLON CANCER AFTER COMBINED TREATMENT Russian patent published in 2023 - IPC A61B5/00 G01N33/48 G01N33/53 G01N33/574 

FIELD: medicine, oncology.

SUBSTANCE: histological material of the tumor is examined. Pathomorphological assessment is performed with assignment of points of the degree of histological malignancy of the tumor and the depth of invasion of the intestinal wall. Using immunohistochemical analysis the expression of markers FRMD6, ZEB1, Ki67 in the tumor tissue is determined. After that, the probability of developing hematogenous metastases P is calculated according to the original formula, if the value of P is ≥50% the risk of developing distant metastases is considered high, and if the value of P is <50% the risk of developing distant metastases is considered low.

EFFECT: method allows to increase the accuracy, information content and availability of the definition of metastatic spreading; makes it possible to obtain an individual risk profile for the development of distant metastasis for a particular patient, and this, in turn, makes it possible to early identify patients requiring increased attention and take more active diagnostic and therapeutic measures; is not difficult to use due to the use of routine methods of pathomorphological diagnostics and immunohistochemical analysis, which simplifies its practical use.

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