METHOD OF CORRECTION OF STREPTOZOTOCIN-INDUCED DIABETES MELLITUS IN RATS USING A HETEROCYCLIC AMIDE-BASED DRUG Russian patent published in 2019 - IPC G09B23/28 A61K31/40 A61K31/4164 A61P3/10 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and aims at correction of type 2 diabetes mellitus experimentally. Method includes simulating experimental type 2 diabetes mellitus by intraperitoneal single administration of streptozotocin in dose of 65 mg/kg with preliminary, within 15 minutes, single intraperitoneal introduction of nicotinamide in dose of 230 mg/kg, then pathology is corrected by intragastric administration of 4-(4,5-dihydro-1H-imidazol-2-yl)-1-methyl-5-phenylpyrrolidine-2-carboxylic acid amide in dose of 8.6 mg/kg starting from 7^th day to 21^st day after introduction of streptozotocin.

EFFECT: method enables considerably reducing blood glucose concentration in rats and reducing the signs of pancreatic injury as compared to diacamph therapy.

1 cl, 8 tbl, 1 dwg, 1 ex