FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology, and can be used for studying the pathophysiology of osteoporosis on the background of diabetes mellitus and searching for innovative preparations for treating complications of diabetes mellitus. A method for modeling osteoporosis with a background of streptozotocin-induced diabetes mellitus involves administering streptozotocin single dose 45 mg/kg intravenously into a tail vein in Wistar rats with further glycemia monitoring, then 7 days after the first introduction, streptozotocin 20 mg/kg is repeated in animals with glycemia level less than 15 mmol/l; thereafter, bone density is analyzed on 57th day using a multispectral imaging system apparatus.
EFFECT: invention provides reduced mortality in animals with high sensitivity to streptozotocin and reduced percentage of recovery in animals with low susceptibility to streptozotocin.
1 cl, 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF EXPERIMENTAL MODELING OF TYPE 2 DIABETES MELLITUS IN COMBINATION WITH MENOPAUSE IN FEMALE WISTAR RATS | 2022 |
|
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| METHOD OF TREATING DIABETES MELLITUS AND COMBINED MEDICATION | 2013 |
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|
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| METHOD OF MODELLING TYPE I DIABETES MELLITUS IN RATS | 2009 |
|
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| DRUG FOR REDUCING INSULIN RESISTANCE AND FOR TREATING DIABETES, METHOD OF REDUCING INSULIN RESISTANCE, METHOD OF TREATING DIABETES AND METHOD OF TREATING DIABETES WITH INSULIN AND/OR HYPOGLYCEMIC PREPARATIONS | 2011 |
|
RU2509572C2 |
| METHOD OF CORRECTION OF STREPTOZOTOCIN-INDUCED DIABETES MELLITUS IN RATS USING A HETEROCYCLIC AMIDE-BASED DRUG | 2018 |
|
RU2687979C1 |
| DRUG SUBSTANCE FOR REDUCING INSULIN RESISTANCE AND TREATING DIABETES MELLITUS AND METHOD FOR PROVIDING HIGHER THERAPEUTIC EFFECTIVENESS IN DIABETES MELLITUS WITH INSULIN AND/OR ANTIHYPERGLYCEMIC MEDICATIONS | 2010 |
|
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| OXOVANADIUM (IV) COMPLEX IN DIMETHYL SULPHOXIDE POSSESSING ANTIDIABETIC ACTION AND METHOD FOR PRODUCING IT | 2014 |
|
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| METHOD OF CORRECTING MICROCIRCULATION IN BONE TISSUE WITH L-NORVALIN IN CASE OF EXPERIMENTAL OSTEOPOROSIS AND FRACTURES AT ITS BACKGROUND | 2013 |
|
RU2540926C1 |
| METHOD OF CORRECTING MICROCIRCULATION IN BONE TISSUE WITH COMBINATION OF L-NORVALIN AND ROSUVASTATIN IN CASE OF EXPERIMENTAL OSTEOPOROSIS AND FRACTURES AT ITS BACKGROUND | 2013 |
|
RU2540927C1 |
