METHOD FOR DETERMINING DEGREE OF BRONCHIAL OBSTRUCTION IN PATIENTS WITH BRONCHIAL ASTHMA AND ACCOMPANYING OBESITY Russian patent published in 2019 - IPC G01N33/53 G01N33/50 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to therapy, and can be used for determining degree of bronchial obstruction in patients with bronchial asthma (BA) and accompanying obesity. Venous blood is used to determine the level of diagnostic values: leptin level (Leptin), ng/ml, resistin level (Resistin), ng/ml, level 25-OH vitamin D (Vitamin D), ng/ml, level γ-interferon (Interferon γ), pg/ml, level of interleukin-4 (IL-4), pg/ml, level of neuropeptide Y (Neuropeptide Y), ng/ml, degree of total oxidative damage of biological molecules (PerOx), mcmole/l, level of tumor necrosis factor alpha (TNF-α), pg/ml. Based on the obtained data, the volume of forced expiratory flow (FEV₁) by formula: FEV₁=222.984 - 2.5686 * IL-4 - 4.1343 * Interferon γ + 1.20847 * Vitamin D + 0.796351 * Leptin + 1.55671 * Resistin - 4.75488 * Neuropeptide Y - 0.0135346 * PerOx - 66.5565 * TNF-α. If value is 100.0 %<FEV₁≥80.0 % shows mild degree of bronchial obstruction. At value of 79.9 %≤FEV₁≥60.0 % define bronchial obstruction of moderate severity. At FEV₁≤59.9 % value define a severe degree of bronchial obstruction.

EFFECT: method provides determining the degree of bronchial obstruction in the patients with asthma and accompanying FEV₁ obesity due to single-step recording of a set of diagnostically significant for this definition degree of obstruction of indicators.

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