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2 695 333

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IPC

A61K38/43(2006-01-01)

A61P13/12(2006-01-01)

(21) (22)

Application

2018133652, 2018-09-24

(24)

Start date

2018-09-24

(22)

Actual filing date

2018-09-24

(45)

Published

2019-07-23

(72)

Inventor

Elagin Vladislav ViktorovichBratchikov Oleg IvanovichPokrovskij Mikhail VladimirovichPokrovskaya Tatyana GrigorevnaKostina Darya AleksandrovnaGureev Vladimir VladimirovichKorokin Mikhail ViktorovichKorokina Liliya Viktorovna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR PREVENTING ISCHEMIA-REPERFUSION RENAL INJURIES WITH AN INHIBITOR OF ARGINASE II IN EXPERIMENT Russian patent published in 2019 - IPC A61K38/43 A61P13/12

Abstract RU 2695333 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to experimental pharmacology and urology, and concerns preventing ischemia-reperfusion renal injuries. For this purpose, Wistar rats 120 minutes before simulating renal ischemia by applying non-traumatic clamps on renal pedicles for 40 minutes followed by reperfusion of blood flow, arginase II KUD975 inhibitor 3 mg/kg is administered intragastrically through a probe.

EFFECT: method provides effective prevention of renal ischemia-reperfusion injury, including due to endothelium-protective properties of the preparation administered at the experimentally established time.

1 cl, 1 ex, 2 tbl

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RU 2 695 333 C1

Authors

Elagin Vladislav Viktorovich

Bratchikov Oleg Ivanovich

Pokrovskij Mikhail Vladimirovich

Pokrovskaya Tatyana Grigorevna

Kostina Darya Aleksandrovna

Gureev Vladimir Vladimirovich

Korokin Mikhail Viktorovich

Korokina Liliya Viktorovna

Dates

2019-07-23—Published

2018-09-24—Filed