FIELD: medicine.
SUBSTANCE: present invention refers to medicine, namely to experimental pharmacology and urology, and concerns preventing ischemia-reperfusion renal injury experimentally. That is ensured by administering asialised erythropoietin to male rats of Wistar line. Renal pathology is then simulated by applying atraumatic clamps on renal peduncles with subsequent reperfusion of blood flow in 40 minutes. Asialised erythropoietin is administered in dose of 2.4 mcg/kg intraperitoneal by 30 minutes before simulating the pathology.
EFFECT: method provides effective prevention of renal ischemic injuries by improving microcirculation processes.
1 cl, 1 ex, 1 tbl
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Authors
Dates
2019-08-07—Published
2018-09-24—Filed