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RU

(11)

2 479 872

(13)

C1

(51)

IPC

G09B23/28(2006-01-01)

A61K31/195(2006-01-01)

A61P1/16(2006-01-01)

A61P9/10(2006-01-01)

A61B17/12(2006-01-01)

(21) (22)

Application

2012100863/14, 2012-01-11

(24)

Start date

2012-01-11

(22)

Actual filing date

2012-01-11

(45)

Published

2013-04-20

(72)

Inventor

Lopatin Dmitrij VladimirovichPokrovskij Mikhail VladimirovichLoktionov Aleksej LeonidovichKonoplja Aleksandr IvanovichDenisjuk Tat'Jana AlekseevnaTsepeleva Svetlana Aleksandrovna

(73)

Holder

Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii

METHOD FOR CORRECTION OF ISCHEMIC DISORDERS CAUSED BY REPERFUSION LIVER INJURY Russian patent published in 2013 - IPC G09B23/28 A61K31/195 A61P1/16 A61P9/10 A61B17/12 

Abstract RU 2479872 C1

FIELD: medicine.

SUBSTANCE: correction of ischemic disorders caused by reperfusion liver injury in experiment in white Wistar male rats involves modelling an ischemic and reperfusion liver injury. 30 Minutes before, L-norvalin arginase blocker 10 mg/kg is introduced intraperitoneally, and distant ischemic pre-conditioning is conducted. Then, another dose of L-norvalin arginase blocker is introduced immediately after liver ischemia.

EFFECT: effective correction of the hepatocellular damage ensured by minimising the oxidative stress effects.

1 tbl, 1 ex

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RU 2 479 872 C1

Authors

Lopatin Dmitrij Vladimirovich

Pokrovskij Mikhail Vladimirovich

Loktionov Aleksej Leonidovich

Konoplja Aleksandr Ivanovich

Denisjuk Tat'Jana Alekseevna

Tsepeleva Svetlana Aleksandrovna

Dates

2013-04-20—Published

2012-01-11—Filed

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