METHOD FOR CORRECTING MICROCIRCULATION DISORDERS IN KIDNEY WITH PEPTIDE THAT MIMICS ALPHA-HELIX B OF ERYTHROPOIETIN IN ISCHEMIA-REPERFUSION INJURY Russian patent published in 2021 - IPC A61K38/08 A61P13/12 

Abstract RU 2751413 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology and urology, and can be used to correct disorders of microcirculation in the kidney. A method for correcting microcirculation disorders in a kidney involves reproducing a model of ischemia-reperfusion kidney injuries by applying atraumatic vascular clamps to laboratory rats on the left renal pedicle for 40 minutes. To correct microcirculation, a peptide that mimics the a-helix B of erythropoietin - pHBSP is injected intraperitoneally at a dosage of 25 mcg/kg once 30 minutes before ischemia.

EFFECT: invention provides creation of an effective method for correcting microcirculation in the kidney when modeling ischemia-reperfusion kidney damage.

1 cl, 1 ex, 1 tbl

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Authors

Netrebenko Aleksandr Sergeevich

Gureev Vladimir Vladimirovich

Korokin Mikhail Viktorovich

Pokrovskij Mikhail Vladimirovich

Soldatov Vladislav Olegovich

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Gudyrev Oleg Sergeevich

Shkodkin Sergej Valentinovich

Zatolokina Mariya Alekseevna

Pobeda Anna Sergeevna

Pokrovskij Vladimir Mikhajlovich

Korokina Liliya Viktorovna

Gureeva Anastasiya Vladimirovna

Kochkarova Indira Sultanovna

Kolesnik Inga Mikhajlovna

Burda Yurij Evgenevich

Alekhin Sergej Aleksandrovich

Kostina Darya Aleksandrovna

Poltev Vladimir Yurevich

Dates

2021-07-13Published

2021-03-10Filed