LIQUID INHALATION COMPOSITION CONTAINING RPL554 Russian patent published in 2019 - IPC A61K9/12 A61K31/519 A61K47/00 A61P11/00 

FIELD: chemistry; pharmaceutics.

SUBSTANCE: group of inventions relates to the chemical-pharmaceutical industry and is a nebulizer containing a liquid pharmaceutical composition and the composition itself suitable for administration by inhalation, containing a pharmaceutically acceptable diluent and a suspension of particles of 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554) or a pharmaceutically acceptable salt thereof, wherein RPL554 particles have a particle size distribution with a Dv50 value of 0.2 to about 5 mcm. Inventions also include a method of treating or preventing respiratory diseases.

EFFECT: suspension of particles RPL554 possesses improved pharmacokinetic properties, stability, provides delayed release profile as compared to composition RPL554 in form of solution.

21 cl, 3 dwg, 27 tbl, 9 ex