DRUG COMBINATION Russian patent published in 2018 - IPC A61K31/495 A61K31/519 A61P11/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, in particular to compositions for treating a disease or condition associated with acute or chronic obstruction of blood vessels or bronchi, or acute or chronic inflammation, as well as to methods of treatment. Composition comprises (a) a PDE3/PDE4 inhibitor which is 9,10-dimethoxy-2-(2,4,6-trimethylphenylamino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one, or a pharmaceutically acceptable acid addition salt thereof, and (b) a muscarinic receptor antagonist. Also disclosed are pharmaceutical compositions for the treatment of a disease or condition associated with acute or chronic obstruction of blood vessels or bronchi or with acute or chronic inflammation. Also disclosed are methods of treating a disease or condition associated with acute or chronic obstruction of blood vessels or bronchi or acute or chronic inflammation.

EFFECT: group of inventions provides a synergistic effect of the combination of RPL554 with muscarinic receptor antagonists.

15 cl, 19 dwg, 4 tbl, 7 ex