FIELD: biotechnology.
SUBSTANCE: invention relates to the biotechnology. Described is a vaccine for enhancing the immune response in birds against an antigen expressed by a herpesvirus vector vaccine. Vaccine contains an effective amount of a vector based on live herpes virus, oligodeoxynucleotide and a pharmaceutically acceptable carrier. Vector based on live herpes virus contains a heterologous nucleotide sequence coding an antigen from a microorganism which is pathogenic for birds, and the oligodeoxynucleotide is an agonist of the Toll-like receptor (TLR) of 21 birds.
EFFECT: addition of the oligodeoxynucleotide, which is a bird TLR21 agonist, into a vector herpesvirus vaccine provides an intensified immune response against the antigen expressed and delivered by the herpes virus vector.
11 cl, 1 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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|
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RU2587633C2 |
