IMPROVED METHOD OF PRODUCING O-METHYLOXIME (E)-(5,6-DIHYDRO-1,4,2-DIOXAZIN-3-YL)(2-HYDROXYPHENYL)METHANONE Russian patent published in 2019 - IPC C07D273/01 C07D413/12 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing O-methyloxime (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone, which includes (i) a reaction of O-methyloxime benzofuran-3(2H)-one (1) with one nitrite selected from n-butyl nitrite and tert-butyl nitrite in the presence of a metal alkoxide selected from lithium alkoxide, sodium alkoxide, potassium alkoxide, rubidium alkoxide, cesium alkoxide, obtaining a composition, where one isomer predominates, and O³-methyl dioxime(2Z, 3Z)-2,3-benzofurandione (2) is basic isomer

(ii) reaction O³-methyldioxime(2Z, 3Z)-2,3-benzofurandione (2) with 2-halogenethanol, obtaining O²-(2-hydroxyethyl)O³-methyl dioxime(2Z, 3Z)-benzofuran-2,3-dione (3)

and (iii) reaction of O²- (2-hydroxyethyl) O³-methylenedimine(2Z, 3Z)-benzofuran-2,3-dione (3) with an acid to obtain O-methyloxime (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone (4)

.

EFFECT: technical result is a novel method of producing O-methyloxime (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl) methanone, which is an intermediate compound for producing fluoxastrobin used in agriculture for combating fungal diseases and pests.

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