METHOD FOR PRODUCING NITROXOLINE Russian patent published in 2019 - IPC C07D215/28 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a method of producing pharmacopoeial nitroxoline (5-nitro-8-oxyquinoline), according to which acetone, technical nitroxoline and activated carbon are loaded into the reactor, then, starting from the second loading, commercial acetone and regenerated acetone are loaded into reactor ratio 2:3, then reaction mass in reactor is heated to temperature of 60 ± 5 °C and held for 1.0–2.0 hours, then the reaction mass is transferred through the other filter into the crystallizer reactor, in which purified water is preliminarily loaded, after which the reaction mass is cooled to temperature of 20 ± 5 °C and held for 1.5–3.0 hours, the obtained pharmacopoeial nitroxaline paste is filtered, wrung out and washed with purified water, then the content of chlorides and sulphates in the paste is analyzed, to content of chlorides in it of not more than 0.02 %, and sulphates of not more than 0.02 %, after that, the pharmacopoeial nitroxyxoline paste is transferred for drying, which is carried out at temperature of 60 ± 15 °C to achieve loss in weight during drying of not more than 0.5 %.

EFFECT: technical result is a method of producing pharmacopoeial nitroxoline (5-nitro-8-oxyquinoline), characterized by high output of the desired compound and less impurity chloride and sulphate.

1 cl