METHOD FOR OBTAINING XANTINOL NICOTINATE Russian patent published in 2018 - IPC A61K31/465 A61K31/52 

FIELD: chemistry; medicine; pharmaceuticals.

SUBSTANCE: invention relates to the field of organic chemistry and discloses a process for the preparation of xantinol nicotinate. Method is characterized in that epichlorohydrin is added to the aqueous solution of theophylline, the reaction mass is heated and maintained, then in three stages, with increasing temperature, an aqueous solution of sodium hydroxide is charged at each loading, the reaction mass is cooled to a temperature of 10±5 °C, after removing the precipitate, filtering and washing 7-(2-hydroxy-3-chloropropyl) theophylline is dissolved in isopropyl alcohol at a temperature of 80±10 °C, sequentially load methylaminoethanol, solution of sodium hydroxide with aging of the reaction mass for 80±10° C and pH 7.5–10, and active carbon followed by aging and filtration of sodium chloride and carbon, the compendial nicotinic acid is loaded with heating, aging and self-cooling of the reaction mass, then the reaction mass is filtered off, washed with isopropyl alcohol and recrystallized in isopropyl alcohol.

EFFECT: invention makes it possible to obtain xantinol nicotinate of compendial grade.

1 cl