LYOPHILIZATE FOR PREPARING RADIOPHARMACEUTICAL AGENT Russian patent published in 2019 - IPC A61K51/00 A61K103/00 A61K38/04 A61P35/00 

Abstract RU 2702238 C2

FIELD: medicine.

SUBSTANCE: invention refers to nuclear medicine and can be used for preparing a radiopharmaceutical containing gallium-68 for detecting neovascularisation. Disclosed is a lyophilizate containing NODAGA-RGD2 peptide and sodium acetate. For the preparation of the lyophilizate, solution containing 0.002 g of NODAGA-RGD2 peptide and 1.64 g of sodium acetate in 100 ml of water for injection is used, wherein lyophilisation solution is packed in 1 ml into bottles, and when Ga-68 solution is added in form of 2 ml of generator 68Ge/68Ga eluate in 0.1 M HCl to one flask of lyophilizate, radiopharmaceutical is obtained with high radiochemical purity in the form of isotonic solution.

EFFECT: invention enables to obtain a radiopharmaceutical drug of high radiochemical purity in the form of an isotonic solution with acidity, which enables intravenous administration to the patient.

1 cl, 4 dwg, 1 tbl, 5 ex

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RU 2 702 238 C2

Authors

Bruskin Aleksandr Borisovich

Rakhimov Marat Galievich

Klementeva Olga Evgenevna

Shimchuk Grigorij Gennadievich

Luneva Kristina Andreevna

Lunev Aleksandr Sergeevich

Dates

2019-10-07Published

2017-10-30Filed