METHOD FOR PRODUCING COMPLEXES BASED ON GALLIUM-68 ISOTOPE Russian patent published in 2021 - IPC C07B59/00 A61K51/04 A61K103/00 

FIELD: medicine.

SUBSTANCE: invention relates to the field of nuclear medicine, namely, to a method for producing gallium-68 complexes. The method includes implementation of a complexation reaction between a ⁶⁸Ga isotope and molecules containing chelating groups of PSMA-11 or DOTA and derivatives thereof, wherein the reaction is conducted in a buffer medium - tris(2-hydroxyethyl)ammonium [NH(CH₂CH₂OH)₃](C₆H₅CO₂) benzoate under conditions of low-temperature radio labelling at 37°C.

EFFECT: invention provides a possibility of producing gallium-68 complexes with a high radiochemical conversion and with a minimum acceptable content of impurities in the form of unbound gallium and/or colloidal gallium under conditions of low-temperature radio labelling.

3 cl, 1 dwg, 3 tbl, 11 ex