DICLOFENAC SODIUM COMPOSITION FOR TOPICAL APPLICATION Russian patent published in 2019 - IPC A61K9/107 A61K31/196 A61K47/02 A61K47/10 A61K47/32 A61K47/44 A61P29/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention refers to pharmaceutical industry and represents a pharmaceutical composition in the form of a gel or an emulsion gel for topical application containing: (a) 2 % diclofenac sodium salt, (b) at least 55 % water, (c) from 10 to 15 % of isopropyl alcohol, (d) from 10 to 15 % of propylene glycol, (e) from 2 to 3 % of at least one gelling agent selected from a group consisting of carbomers, (f) from 0 to 10 % of liquid lipid, which forms oil phase, (g) from 0 to 5 % of at least one nonionic surfactant, and (h) a basic agent for bringing the whole of the composition pH to 6–9, all percentages being weight, where (c) and (d) together form 20 to 25 % of the composition, and the viscosity of the composition is in range of 5,000 to 10,000 cP.

EFFECT: invention provides high degree of penetration through skin, absence of irritant action, high stability, complete solubility of active ingredient and effective pain relief.

10 cl, 5 ex, 2 tbl, 5 dwg