FIELD: medicine; pharmaceutical industry.
SUBSTANCE: invention relates to medicine, namely to the pharmaceutical industry, and concerns dosage forms (DF) in the form of gel and spray for the treatment or prevention of wound and hospital infections. A drug for the treatment or prevention of hospital and wound infections contains a mixture of recombinant endolysins LysECD7, LysAm24, and LysAp22, at a concentration of 0.03-0.15 wt.%, and auxiliary components. At the same time, the drug in the form of gel contains a gel-forming agent, PEG 1500 or PEG 3000, and a buffer solution with pH of 7.0-8.0. The drug in the form of spray contains Poloxamer 338 or Poloxamer 407, PEG 1500 or PEG 3000, and a buffer solution with pH of 7.0-8.0.
EFFECT: drugs provide a local antibacterial effect by applying them to a wound surface or administering in the abscess cavity, have a wide range of action, without affecting representatives of normal flora of the gastrointestinal tract.
2 cl, 4 dwg, 9 tbl, 6 ex
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