METHOD AND INTERMEDIATE COMPOUNDS FOR PRODUCING 5-BIPHENYL-4-IL-2-METHYLPENTANIC ACID DERIVATIVES Russian patent published in 2017 - IPC C07C269/06 C07C271/22 C07C227/22 C07D207/38 

Abstract RU 2636936 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a novel process for producing NEP inhibitors, in particular NEP inhibitors containing γ-amino-δ-biphenyl-α-methylalkane acid or acid ester as a frame. More specifically, new methods in accordance with the present invention relate to the synthesis of intermediates for producing the above NEP inhibitors, namely compounds of the formula (1) or their salts, where R1 and R2 are independently hydrogen or a protective group for nitrogen, and R3 is a carboxylic group or an ester group, preferably a carboxyl group or alkyl ester.

EFFECT: improved method.

28 cl, 4 tbl, 77 ex

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RU 2 636 936 C2

Authors

Khuk Dejvid

Riss Bernkhard

Kaufmann Daniel

Napp Mattias

Bappert Erkhard

Polle Filipp

Medlok Dzhonatan

Tsanotti-Gerosa Antonio

Dates

2017-11-29Published

2013-10-31Filed