FIELD: chemistry.
SUBSTANCE: invention relates to a novel process for producing NEP inhibitors, in particular NEP inhibitors containing γ-amino-δ-biphenyl-α-methylalkane acid or acid ester as a frame. More specifically, new methods in accordance with the present invention relate to the synthesis of intermediates for producing the above NEP inhibitors, namely compounds of the formula (1) or their salts, where R1 and R2 are independently hydrogen or a protective group for nitrogen, and R3 is a carboxylic group or an ester group, preferably a carboxyl group or alkyl ester.
EFFECT: improved method.
28 cl, 4 tbl, 77 ex
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Authors
Dates
2017-11-29—Published
2013-10-31—Filed