FIELD: medicine.
SUBSTANCE: invention relates to biochemistry and medicine. Disclosed is a compound for use in transmembrane drug delivery, having structure (VI), (VII), (VIIa), (VIII), (IX) or (IXa), as given in formula. Molecule structure creates a vector system which promotes movement of the molecule within the phospholipid membrane from the membrane/water interface to the membrane core.
EFFECT: compounds can be used in medical practice, for example in delivery of natural or modified RNA or DNA, low interfering RNA (siRNA), antisense oligonucleotide (ASO) or therapeutic protein, CRISPR protein, daiser substrate containing a double stranded RNA of 25–30 nucleotides, which includes a sequence of the targeting gene for side hair, or any combination thereof through biological membranes for treating diseases.
3 cl, 5 dwg, 7 ex
