Show metadata Hide metadata

(19)

(11)

2 716 420

(13)

(51)

IPC

C12N15/63(2006-01-01)

C12N9/22(2006-01-01)

C12N5/10(2006-01-01)

C12N15/113(2010-01-01)

A61K48/00(2006-01-01)

A61P1/16(2006-01-01)

(21) (22)

Application

2016101200, 2014-06-10

(24)

Start date

2014-06-10

(22)

Actual filing date

2014-06-10

(45)

Published

2020-03-11

(72)

Inventor

Chzhan FenTsun LeZhan Fej

(73)

Holder

Te Brod Instityut Ink.Massachusets Instityut Of TeknolodzhiPrezident End Fellouz Of Kharvard Kollidzh

DELIVERY AND USE OF SYSTEMS OF CRISPR-CAS, VECTORS AND COMPOSITIONS FOR TARGETED ACTION AND THERAPY IN LIVER Russian patent published in 2020 - IPC C12N15/63 C12N9/22 C12N5/10 C12N15/113 A61K48/00 A61P1/16

Abstract RU 2716420 C2

FIELD: biotechnology.

SUBSTANCE: disclosed is a composition containing a CRISPR/Cas system for use in treating a liver disease or disorder.

EFFECT: said system due to the presence of at least one nuclear localization signal (NLS) enables efficient editing of the eukaryotic cell genome, in connection with which it can be used to edit genes associated with hepatic diseases in mammals.

20 cl, 98 dwg, 3 tbl, 41 ex

Similar patents RU2716420C2

Title	Year	Author	Number
DELIVERY, CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED ACTION AND MODELING OF DISEASES AND DISORDERS OF POSTMITOTIC CELLS	2014	Chzhan Fen Khajdenrajkh Mattias Suich Lukash	RU2725502C2
DELIVERY, USE AND USE IN THERAPY OF CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETED ACTION ON DISORDERS AND DISEASES USING VIRAL COMPONENTS	2014	Chzhan Fen Tsun Le Zhan Fej Khajdenrajkh Mattias Suich Lukash	RU2716421C2
CRISPR-CAS SYSTEMS AND METHODS OF CHANGING EXPRESSION OF GENE PRODUCTS	2013	Chzhan Fen	RU2687451C1
DELIVERY, CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND USE IN THERAPY	2013	Chzhan Fen Khajdenrajkh Mattias Zhan Fej Suich Lukash	RU2721275C2
DESIGNING SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR MANIPULATING SEQUENCES	2013	Chzhan Fen Tsun Le Khsyu Patrik Ran Fej	RU2701850C2
CRISPR-CAS SYSTEM COMPONENTS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION	2013	Chzhan Fen Bikard Devid Olive Tsun Le Koks Devid Bendzhamin Turits Khsyu Patrik Tszyan Venyan Lin Shaujlyan Marraffini Luchano Platt Rendol Dzheffri Zhan Fej Sandzhana Nevill Espi	RU2701662C2
CRISPR ENZYME MUTATIONS REDUCING NON-TARGETED EFFECTS	2016	Zhang Feng Gao Linyi Zetsche Bernd Slaymaker Ian	RU2752834C2
CRISPR-CAS SYSTEMS AND METHODS FOR CHANGING THE EXPRESSION OF GENE PRODUCTS	2013	Zhang, Feng	RU2796273C2
GENE EDITING OF DEEP INTRON MUTATIONS	2016	Ruan, Guoxiang Scaria, Abraham	RU2759335C2
SYSTEM DESIGN, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION	2013	Zhang, Feng Cong, Le Hsu, Patrick Ran, Fei	RU2796017C2

RU 2 716 420 C2

Authors

Chzhan Fen

Tsun Le

Zhan Fej

Dates

2020-03-11—Published

2014-06-10—Filed