AGENT FOR TREATING HORMONE-DEPENDENT TUMORS AND A METHOD FOR PRODUCTION THEREOF Russian patent published in 2019 - IPC A61K38/08 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and concerns an agent for treating adenocarcinoma of mammary gland containing methyl ester N^α-tert-butyloxycarbonyl-S-tetrahydropyranylcysteinyl-phenylalanyl-D-tryptophyl-N^ε-benzyl-oxycarbonyl-precyltreonine (P), where the agent is a lyophilizate for preparing an injection solution, additionally contains phosphatidyl choline (PCH), cholesterol (CH) and DSPE-PEG-2000 (PEG-lipid) and saccharose (S) in molar ratio of components: M_P:M_PCH:M_CH:M_PEG-lipid:M_S=1.0:71.1:13.9:0.2:346.5. Group of inventions also relates to a method of producing said agent, involving dissolving P, PS, CH and PEG-lipid, taken in ratio of 1.0:71.1:13.9:0.2, evaporation of the formed chloroform solution on a rotary evaporator under vacuum, dispersion of the film formed during evaporation, filtration and extrusion of the obtained liposomal dispersion, addition of cryoprotector solution, dosing and stabilization by lyophilisation.

EFFECT: group of inventions provides higher bioavailability and anticancer activity of the drug.

2 cl, 1 tbl, 3 ex