OPHTHALMIC COMPOSITIONS FOR DRUG DELIVERY AND EYE ANTERIOR SEGMENT Russian patent published in 2019 - IPC A61K9/08 A61K9/10 A61K31/122 A61K31/425 A61K31/455 A61P27/02 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine, namely to ophthalmology, is intended for treating and/or reducing the intensity of the posterior eye disease. Ophthalmic suspension composition for topical application contains: a) a first active substance of formula II:

(II)

or a pharmaceutically acceptable salt thereof; b) a second active substance or a pharmaceutically acceptable salt thereof, wherein the second active substance is nicotinic acid, nicotinamide or vitamin K, or a combination thereof; and c) a pharmaceutically acceptable excipient. First active substance or its pharmaceutically acceptable salt is present in amount of 0.005 % to 5.0 % w/v. Said composition is used to produce a drug suitable for accessing the posterior eye and/or for treating and/or reducing the intensity of such a posterior eye disease, such as diabetic retinopathy, age-related macular degeneration, pathological neovascularisation of the choroid, pathological retinal neovascularization, uveitis, retinal vein occlusion, eye injury, surgical induced oedema, surgical-induced neovascularisation, cystic macular oedema, ischemia of the eye, retinopathy of prematurity, Coates's disease, sickle-cell retinopathy, neovascular glaucoma.

EFFECT: using the group of inventions enables providing higher clinical effectiveness and/or reducing the intensity of the vascular or inflammatory back eye disease.

21 cl, 41 tbl, 11 dwg, 26 ex