OPHTHALMIC FORMULATIONS FOR DRUG DELIVERY AND ANTERIOR EYE PROTECTION Russian patent published in 2022 - IPC A61K9/08 A61K9/10 A61K31/122 A61K31/425 A61K31/455 A61P27/02 

FIELD: medicine; ophthalmology.

SUBSTANCE: group of inventions is intended for treating and/or reducing the intensity of a posterior eye disease. Ophthalmic suspension formulation for topical application contains particles of an active substance of formula II or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients. Said active substance or its pharmaceutically acceptable salt is present in an amount of approximately 0.005 % to approximately 5.0 % (w/v). Said particles have an average diameter of 100 nm to 100 mcm. Ophthalmic suspension formulation is used to prepare a drug suitable for accessing the posterior eye and/or for treating and/or reducing the intensity of the posterior eye disease.

EFFECT: use of the group of inventions provides the combined effects of reducing the effect of drugs on the cornea and anterior part of the eye and protecting the cornea and tissues of the anterior part of the eye, while increasing the bioavailability of the posterior part of the eye, and also enables improving ophthalmic tolerance and increasing the therapeutic index of the active substance.

21 cl, 11 dwg, 22 tbl, 26 ex