METHOD FOR PREDICTING THE RISK OF THE UNFAVORABLE OUTCOME IN THE PATIENTS SUFFERING ISCHEMIC HEART DISEASE WITHIN THE YEAR FOLLOWING CORONARY ARTERIAL BYPASS Russian patent published in 2019 - IPC G01N33/577 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology, and can be used for prediction of risk of unfavorable outcome in patients with ischemic heart disease within a year after coronary artery bypass. Patients with ischemic heart disease on the first day of admission to hospital, prior to coronary artery bypass grafting, by flow cytofluorometry, phenotyping TLR9 in peripheral blood monocytes, %, using monoclonal antibodies. A prognostic coefficient K is calculated by formula: K = exp (-11.7 + 0.15 * x)/(1 + exp (-11.7 + 0.15) * x)), where K is a prognostic coefficient reflecting a probability of developing a negative cardiovascular event, and x is a value of the initial expression of TLR9 by monocytes, %. Constant value 11.7 and coefficient 0.15 before variable x are obtained by logistic regression by experimental method. At value K ≥ 0.639 predict a high risk of developing a negative cardiovascular event in the year following coronary artery bypass grafting. If K < 0.639, the risk of developing a negative cardiovascular event is low.

EFFECT: method provides predicting a risk of developing a negative cardiovascular event in patients with ischemic heart disease within the year following coronary artery bypass grafting due to patient's phenotyping TLR9 in peripheral blood monocytes using monoclonal antibodies and calculating prognostic coefficient by formula obtained by logistic regression method.

1 cl, 2 dwg, 2 ex