EFFERVESCENT COMPOSITIONS AND METHODS FOR PRODUCTION AND USE THEREOF Russian patent published in 2019 - IPC A61K9/16 A61K9/46 A61K47/02 A61K47/12 

FIELD: medicine.

SUBSTANCE: group of inventions relates to effervescent compositions and methods for production thereof. Disclosed is a granular effervescent composition containing an anhydrous acidic component containing a combination of part of the acid subjected to melting, and a portion of the unmelted acid and an anhydrous basic component containing a carbonate functional group, where the main component is able to react with the acid component to form carbon dioxide; and where anhydrous acid component and anhydrous basic component are in mass ratio in range from 1:9 to 9:1, and composition does not contain granulating agent, different from acid component, which interacts with base, providing release of gas bubbles. Also disclosed are a porous effervescent composition, effervescent oral solid dosage forms based on said acid and base agents, as well as a double-screw treatment device for production of porous effervescent granules and a method for production of porous effervescent granules.

EFFECT: group of inventions provides release of carbon dioxide with effervescent compositions in amount of 90 % of the amount released by the incoming mixture to form data of effervescent compositions, and also provides porosity exceeding the porosity of the incoming mixture by 50 %.

23 cl, 2 dwg, 11 tbl, 4 ex