METHOD FOR PREDICTION OF LETHAL OUTCOME IN HYPERTENSIVE HYDROCEPHALUS SYNDROME IN FULL-TERM NEWBORNS WITH CONGENITAL CYTOMEGALOVIRUS INFECTION Russian patent published in 2019 - IPC G01N33/48 G01N33/53 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to paediatrics, and can be used in prediction of lethal outcome in hypertensive hydrocephalus syndrome in full-term newborns with congenital cytomegalovirus infection. That is ensured by detection of innate cytomegalovirus infection in full-term newborns by umbilical cord blood cytomegalovirus, immunoglobulin (Ig) M antibodies to cytomegalovirus and difference in titre of IgG antibodies to cytomegalovirus in blood serum of mother and umbilical cord blood in newborns (A). Also, the degree of manifestation of ventriculomegalia (B) is stated; by changing contours, structure and echogenicity of vascular plexuses of cerebral lateral ventricles (C); by umbilical cord umbrage factor-α (pg/ml) (N). Thereafter, the lethal outcome is predicted by the discriminant equation D=-1.627×A-2.764×B-4.278×C-0.163×N, where D is a discriminant function with boundary value equal to -24.25. If D is greater than or equal to the boundary value, no lethal outcome is predicted. If D is less than the limit value, the lethal outcome is predicted in the case of hypertension-hydrocele syndrome in newborns with congenital cytomegalovirus infection.

EFFECT: invention provides more accurate prediction of lethal outcome in hypertensive hydrocephalus syndrome in full-term newborns with congenital cytomegalovirus infection.

1 cl, 2 ex