FIELD: organic chemistry; pharmacology.
SUBSTANCE: invention relates to the field of organic chemistry and pharmacology, namely to 2-amino-6-hydroxy-7-(3-oxo-dihydroquinoxalin-2-yl)-7a-phenyl-pyrrolo[2,1-b][1,3,4]thiadiazole-5(7Ah)-on of the general formula
where R1=H (a), Ph (b). The invention also relates to a method for their preparation by reacting 3-benzoyl-2,4-dihydro-1H-pyrrolo[2,1-c][1,4]quinoxaline(5H)-1,2,4-triones with thiosemicarbazide in an anhydrous acetonitrile medium during boiling for 4 hours and subsequent isolation of the target products.
EFFECT: new compounds with anti-inflammatory activity have been obtained, which can be used in pharmacology as potential drugs with anti-inflammatory properties.
2 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| 3A-(4-R-PHENYL)-2-HYDROXY-3-(3-OXO-3,4-DIHYDROQUINOXALIN-2-YL)BENZO[D]PYRROLO[2,1-B]THIAZOL-1(3AH)-ON |
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|
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2021 |
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|
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|
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2023 |
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2018 |
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|
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2019 |
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2023 |
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2021 |
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|
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2023 |
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RU2798467C1 |
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2023 |
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