FIELD: organic chemistry; pharmacology.
SUBSTANCE: invention relates to the field of organic chemistry and pharmacology, namely to 2-amino-6-hydroxy-7-(3-oxo-dihydroquinoxalin-2-yl)-7a-phenyl-pyrrolo[2,1-b][1,3,4]thiadiazole-5(7Ah)-on of the general formula
where R1=H (a), Ph (b). The invention also relates to a method for their preparation by reacting 3-benzoyl-2,4-dihydro-1H-pyrrolo[2,1-c][1,4]quinoxaline(5H)-1,2,4-triones with thiosemicarbazide in an anhydrous acetonitrile medium during boiling for 4 hours and subsequent isolation of the target products.
EFFECT: new compounds with anti-inflammatory activity have been obtained, which can be used in pharmacology as potential drugs with anti-inflammatory properties.
2 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| ANTIMICROBIAL AGENT BASED ON 2-(R-AMINO-6-HYDROXY-7-(3-OXO-3,4-DIHYDROQUINOXALIN-2-yl)-7a-ARYLPYRROLO[2,1-b][1,3,4]THIADIAZOL-5(7aH)-ONES |
2024 |
- Mashevskaia Irina Vladimirovna
- Belozerova Dzhamilia Nailevna
- Balandina Svetlana Iurevna
- Sukhanova Polina Vasilevna
|
RU2830076C1 |
| 3A-(4-R-PHENYL)-2-HYDROXY-3-(3-OXO-3,4-DIHYDROQUINOXALIN-2-YL)BENZO[D]PYRROLO[2,1-B]THIAZOL-1(3AH)-ON |
2022 |
- Mashevskaia Irina Vladimirovna
- Lukmanova Dzhamilia Nailevna
- Dmitriev Maksim Viktorovich
- Balandina Svetlana Iurevna
|
RU2783288C1 |
| (Z)-5-SUBSTITUTED-3-(HYDROXY(ARYL)METHYLENE)-3-(PHENYLTHIO)-3,3А-DIHYDROPYRROLO[1,2-A]QUINOXALINE-1,2,4(5H)TRIONES WITH ANTIMICROBIAL ACTIVITY |
2021 |
- Mashevskaya Irina Vladimirovna
- Balandina Svetlana Yurevna
- Lukmanova Dzhamilya Nailevna
|
RU2759006C1 |
| (Z)-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-2-(((Z)-2-OXOINDOLIN-3-YLIDENE)HYDRAZONO)-1-THIA-3,6-DIAZASPIRO[4.4 ]NON-8-EN-4,7-DIONES WITH ANTIMICROBIAL ACTIVITY |
2021 |
- Mashevskaya Irina Vladimirovna
- Dmitriev Maksim Viktorovich
- Balandina Svetlana Yurevna
- Lukmanova Dzhamilya Nailevna
|
RU2763739C1 |
| METHOD OF PRODUCING 3-AROYL-2-HYDROXY-3A-(1H-INDOL-3-YL)-1H-BENZO[B]PYRROLO[1,2-D][1,4]THIAZINE-1,4(3AH)-DIONES EXHIBITING GROWTH-REGULATING ACTIVITY WITH RESPECT TO CULTURE OF MICROALGAE CHLORELLA VULGARIS |
2023 |
- Maslivets Andrei Nikolaevich
- Lystsova Ekaterina Aleksandrovna
- Khramtsova Ekaterina Evgenevna
- Novokshonova Anastasiia Denisovna
- Khramtsov Pavel Viktorovich
- Raev Mikhail Borisovich
|
RU2825140C1 |
| 2-ARYL-2,4-DIHYDROXY-2,5-DIHYDRO-3-HETERYL-5-OXO-1H-PYRROL-1-YL-4-METHYL BENZENESULPHANOLAMIDES WITH ANALGESIC ACTIVITY |
2015 |
- Suchkova Nadezhda Vladimirovna
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
- Mashevskaya Irina Vladimirovna
|
RU2626650C2 |
| 4-(AROYL)-3-HYDROXY-1-(2-HYDROXYPHENYL)-5-(PHENYLTHIO)-1,5-DIHYDRO-2H-PYRROL-2-ONES EXHIBITING ANTIMICROBIAL ACTIVITY |
2021 |
- Mashevskaya Irina Vladimirovna
- Dmitriev Maksim Viktorovich
- Balandina Svetlana Yurevna
- Lukmanova Dzhamilya Nailevna
|
RU2759008C1 |
| 4 - ((2-ARYL-2,4-DIHYDROXY-5-OXO-3-(3-OXO-3,4-DIHYDROQUINOXALIN-2-YL)-2,5-DIHYDRO-1N-PYRROL-1-YL)AMINO)BENZOIC ACIDS HAVING ANALGESIC ACTIVITY |
2019 |
- Mashevskaya Irina Vladimirovna
- Makhmudov Ramiz Ragibovich
- Prikhodko Yaroslav Igorevich
|
RU2731215C1 |
| METHOD FOR PRODUCING (R*)-3-AROYL-2-HYDROXY-2-((S*)-2-OXOCYCLOALKYL)PYRROLO[1,2-A]QUINOXALINE-1,4(2H,5H)-DIONES |
2018 |
- Maslivets Andrej Nikolaevich
- Kasatkina Svetlana Olegovna
- Stepanova Ekaterina Evgenevna
- Balandina Svetlana Yurevna
|
RU2665060C1 |
| 8-HYDROXY-6-(2-HYDROXYPHENYL)-9-AROYL-1-(PHENYLAMINO)-2-THIOXO-1,3,6-TRIAZASPIRO[4.4]NON-8-ENE-4,7-DIONES, HAVING ANTIMICROBIAL ACTIVITY |
2024 |
- Mashevskaia Irina Vladimirovna
- Belozerova Dzhamilia Nailevna
- Balandina Svetlana Iurevna
- Sukhanova Polina Vasilevna
|
RU2827550C1 |
