FIELD: chemistry.
SUBSTANCE: invention relates to novel ethyl 1,6-diaryl-4-aroyl-3-hydroxy-2-oxo-8-phenyl-1,7-diazaspiro[4,4]nona-3,6,8-trien-9-carboxilates of formula 
, where Ar stands for Ph, C6H4Me-4; R stands for C6H4Me-4, C6H4OMe-4, which demonstrate analgesic activity. Compounds are obtained by interaction of 1-aryl-4,5-diaroly-1H-pyrrole-2,3-dione with ethyl ether of 3-amino-3-phenylpropenoic acid with ratio 1:1 in medium of boiling absolute benzene with further separation of target products.
EFFECT: method improvement.
4 cl, 1 dwg, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| METHOD OF PRODUCING METHYL 1,7-DIARYL-9-AROYL-4-BENZOYL-3-HYDROXY-2,6-DIOXO-1,7-DIAZASPIRO[4,4]NONE-3,8-DIENE-8-CARBOXYLATES, EXHIBITING ANALGESIC ACTIVITY |
2013 |
- Denislamova Ekaterina Sergeevna
- Dubovtsev Aleksej Jur'Evich
- Makhmudov Ramiz Ragibovich
- Maslivets Andrej Nikolaevich
|
RU2537999C1 |
| INTERMEDIATE PRODUCTS - METHYL 7-ARYL-4, 9-DIAROYL-3-HYDROXY-1-(2-HYDROXYPHENYL)-2,6-DIOXO-1, 7-DIAZASPIRO[4,4]NONE-3, 8-DIENE-8-CARBOXYLATES; METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4,10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO[6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHOD OF PRODUCING METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4, 10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHYL 11-BENZOYL-2-O-HYDROXYPHEHYL-3, 4, 10-TRIOXO-9-P-TOLYL-6-PHENYL-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATE HAVING ANTIMICROBIAL ACTIVITY |
2008 |
- Racheva Nadezhda L'Vovna
- Maslivets Andrej Nikolaevich
- Aleksandrova Galina Arsent'Evna
|
RU2383550C1 |
| 2-(6-ARYL-4-AROYL-3-METHYL-1-PHENYL-1H-PYRAZOLO[3,4-b]PYRIDIN-5-YL)-2-OXO-N-ARYLACETAMIDES AND METHODS FOR PRODUCTION THEREOF |
2012 |
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2501800C2 |
| 1,6'-DIARYL-3-AROYL-4-HYDROXY-1',3'-DIMETHYLSPIRO[PIRROLE-2,5'-PYRROLO[2,3-d]PYRIMIDINE]-2',4',5(1H,1'H,3'H)-TRIONES AND METHOD FOR PRODUCTION THEREOF |
2012 |
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2502738C2 |
| METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-1,6-DIPHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-6-STYRYL-1-PHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHOD FOR PREPARING THEM |
2012 |
- Maslivets Andrej Nikolaevich
- Bubnov Nikolaj Vladimirovich
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Makhmudov Ramiz Ragibovich
|
RU2495039C1 |
| 1,1'-DIARYL-3'-AROYL-4'-HYDROXY-1H-SPIRO [INDENO[1,2-b]PYRROL-3,2'-PYRROL]-2,4,5'-(1'H)-TRIONES AND METHOD OF THEIR OBTAINING |
2011 |
- Bubnov Nikolaj Vladimirovich
- Denislamova Ekaterina Sergeevna
- Makhmudov Ramiz Ragibovich
- Maslivets Andrej Nikolaevich
|
RU2467011C1 |
| APPLICATION OF 2-[(R-BENZYLIDENE)HYDRAZONO]-8-HYDROXY-6-(2-HYDROXYPHENYL)-9-AROYL-1-THIA-3,6-DIAZASPIRO[4.4]NONA-8-EN-4,7-DIONES AS AGENTS WITH ANTI-INFLAMMATORY ACTIVITY |
2022 |
- Mashevskaia Irina Vladimirovna
- Lukmanova Dzhamilia Nailevna
- Apushkin Danila Iurevich
- Utushkina Taisiia Andreevna
- Iakushina Karolina Evgenevna
- Andreev Aleksandr Igorevich
|
RU2783241C1 |
| 1'-ARYL-4'-HYDROXY-3'-CYNNAMOYL-2H,4H-SPIRO[FURO[3,2-c]CHROMEN-3,2'-PYRROL]-2,4,5'(1'H)-TRIONES EXHIBITING ANALGESIC ACTIVITY, AND METHOD FOR PRODUCING THEM |
2014 |
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2577523C2 |
| ETHYL 5-ALKYL-7,7-DIMETHYL-2',9,11-TRIOXO-5'-PHENYL-1',2',5,6,7,8,9,11-OCTAHYDROSPIRO{INDENO[1,2-b][QUIOLINE-10,3'-PYRROL}-4'-CARBOXYLATES AND METHOD FOR PREPARING THEM |
2012 |
- Dmitriev Maksim Viktorovich
- Silajchev Pavel Sergeevich
- Makhmudov Ramiz Ragibovich
- Maslivets Andrej Nikolaevich
|
RU2485120C1 |
| METHOD OF PRODUCING 2-AMINO-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-1-THIA-3,6-DIAZASPIRO[4.4]NONA-2,8-DIENE-4,7-DIONE |
2019 |
- Maslivets Andrej Nikolaevich
- Kobelev Aleksandr Ivanovich
- Stepanova Ekaterina Evgenevna
- Balandina Svetlana Yurevna
|
RU2707195C1 |
