FIELD: medicine.
SUBSTANCE: invention refers to medicine and can be used for diagnosing central hypogonadism in females. That is ensured by sampling venous blood, recovering genetic material from leukocytes and quantitative determination of mRNA, which characterizes gene expression PROK2, DUSP6 and WDR11. Additionally, luteinizing hormone is measured by chemiluminescent method. If observing expression level values above reference in at least two of three genes, namely PROK2>0.009356, DUSP6>0.01478 and WDR11>0.002224, as well as luteinizing hormone level less than 1.95 IU/l, central hypogonadism is diagnosed.
EFFECT: invention provides higher diagnostic accuracy of central hypogonadotropic hypogonadism in females.
1 cl, 8 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DIAGNOSTIC METHOD OF CENTRAL HYPOGONADISM IN FEMALES | 2019 |
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| METHOD OF DIAGNOSIS OF FOLLITROPIN AND LUTROPIN HYPERSECRETION | 2000 |
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| METHOD FOR MODELLING MALE HYPOGONADOTROPIC HYPOGONADISM | 2020 |
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| METHOD FOR SIMULATING FEMALE ANOVULATORY INFERTILITY IN RATS | 2015 |
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| METHOD FOR PREDICTING HOLLOW FOLLICLES SYNDROME | 2005 |
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