IMPROVED STRATIFICATION OF PATIENTS TO EVALUATE THERAPY SUITABILITY Russian patent published in 2020 - IPC G01N33/574 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and a method for stratifying a patient to assess the suitability of therapy for a patient suffering from a malignant tumour, wherein the therapy is directed against the signal transmission cascade, comprising a step (i) determining the activation state of the ER and/or PR signalling cascade for detecting in the patient's tissue sample the presence of at least one representative of the ER and/or PR family, wherein said at least one representative is part of a complex of transcription factors, and at least one protein selected from the group consisting of TAF, TBP, POLII, TFII, p300, CREP and CBP, where at least one protein is part of the same complex of transcription factors, where if the signal path of stage (i) is determined as being active, the patient is stratified as suitable for endocrine treatment. Group of inventions also relates to using the kit in said method, the kit comprising a first antibody directed against an ER and/or PR family epitope and a second antibody directed against a protein epitope selected from a group consisting of TAF, TBP, POLII, TFII, p300, CREP and CBP.

EFFECT: group of inventions provides stratification of a patient to assess the suitability of therapy for a patient suffering from a malignant tumour.

13 cl, 3 ex, 6 dwg