FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry, in particular to a genetically modified rodent for the expression of a humanised CD274 polypeptide, the genome of which contains a humanised CD274 gene in the endogenous locus CD274, a method for preparing it, as well as to its cell, tissue and embryo. Also disclosed is a screening method for a medicinal agent capable of treating a tumour involving using said rodent.
EFFECT: invention provides effective screening of a medicament capable of treating a tumour.
24 cl, 6 dwg, 9 tbl, 3 ex
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