FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry, in particular to a genetically modified rodent that producing a human or humanized IL-7 protein. Also disclosed is a nucleic acid encoding a human or humanized IL-7 protein, an ES cell of said rodent, a cell comprising a humanized IL-7 gene, tissue that comprises a humanized IL-7 gene. Also disclosed is a method for making said genetically modified rodent.
EFFECT: invention provides obtaining a human or humanized IL-7 protein.
21 cl, 2 dwg, 1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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RU2726446C2 |
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|
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|
RU2788523C2 |
| ANIMALS WITH HUMANIZED IL-4 AND IL-4Rα | 2015 |
|
RU2703139C2 |
| NON-HUMAN ANIMALS HAVING HUMANIZED Fc-γ-RECEPTORS | 2015 |
|
RU2700484C2 |
