FIELD: medicine; pharmaceuticals.
SUBSTANCE: group of inventions relates to medicine and pharmacy. Disclosed is use of benzene, in which at least 4 H atoms are substituted, and substitutes R1 and R2 independently represent H, F or OH; substitute A - (CH2)mCOOH, W(CH2)mCOOH or Y-CH(COOH)-(CH2)p-CH3, when substitute B - H; or B - (CH2)mCOOH, W(CH2)mCOOH or Y-CH(COOH)-(CH2)p-CH3, when A is H; or A and B are covalently bonded to form five- (5), six- (6) or seven (7) -functional cycloalkyl substituted with COOH; where: Y is O, S, NH or CH2; W is O, S or NH; m = 0–2; and p = 3–7; substitute D - CO (CH2)nCH3 or CHOH (CH2)nCH3, or O (CH2)nCH3, when n = 2–6; and a substitute E - H or F, or a salt thereof for preparing a medicament for preventing and/or treating osteoporosis, use for preparing a medicament for stimulating bone tissue formation and use to produce a medicament for stimulating bone tissue formation or remodelling.
EFFECT: technical result: implementation of the appointment (increased level of collagen in the bones of ovariectomized rats), reduced osteoclastogenesis (by the index of reducing activity of acid phosphatase), stimulation of differentiation and mineralization of osteoblasts (by the index of increased level of IL-12).
24 cl, 7 dwg, 1 tbl, 4 ex
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Authors
Dates
2020-01-27—Published
2015-10-08—Filed