PHENYLKETON CARBOXYLATE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING AND TREATING OSTEOPOROSIS Russian patent published in 2020 - IPC A61K31/192 A61K31/20 A61K31/196 A61K31/222 A61K31/235 A61P19/10 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to medicine and pharmacy. Disclosed is use of benzene, in which at least 4 H atoms are substituted, and substitutes R₁ and R₂ independently represent H, F or OH; substitute A - (CH₂)_mCOOH, W(CH₂)_mCOOH or Y-CH(COOH)-(CH₂)_p-CH₃, when substitute B - H; or B - (CH₂)_mCOOH, W(CH₂)_mCOOH or Y-CH(COOH)-(CH₂)_p-CH₃, when A is H; or A and B are covalently bonded to form five- (5), six- (6) or seven (7) -functional cycloalkyl substituted with COOH; where: Y is O, S, NH or CH₂; W is O, S or NH; m = 0–2; and p = 3–7; substitute D - CO (CH₂)_nCH₃ or CHOH (CH₂)_nCH₃, or O (CH₂)_nCH₃, when n = 2–6; and a substitute E - H or F, or a salt thereof for preparing a medicament for preventing and/or treating osteoporosis, use for preparing a medicament for stimulating bone tissue formation and use to produce a medicament for stimulating bone tissue formation or remodelling.

EFFECT: technical result: implementation of the appointment (increased level of collagen in the bones of ovariectomized rats), reduced osteoclastogenesis (by the index of reducing activity of acid phosphatase), stimulation of differentiation and mineralization of osteoblasts (by the index of increased level of IL-12).

24 cl, 7 dwg, 1 tbl, 4 ex