METHOD OF CORRECTING MICROCIRCULATION IN BONE TISSUE WITH L-NORVALIN IN CASE OF EXPERIMENTAL OSTEOPOROSIS AND FRACTURES AT ITS BACKGROUND Russian patent published in 2015 - IPC A61K31/198 A61P19/10 

Abstract RU 2540926 C1

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine and is intended for impact on microcirculation in bone tissue in case of experimental osteoporosis and fractures at its background. Method includes modelling osteoporosis in female rats of Wistar line by bilateral ovariectomy and osteoporotic fractures and pharmacological correction of pathological states with L-norvalin in dose 10 mg/kg intragastrically, daily, one time per day.

EFFECT: application of claimed invention makes it possible to prevent negative dynamics of indices of microcirculation in bone tissue in case of osteoporosis and in bone callus in case of osteoporotic fractures.

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RU 2 540 926 C1

Authors

Gudyrev Oleg Sergeevich

Radzhkumar Densing Samuehl Radzh

Fajtel'Son Aleksandr Vladimirovich

Pokrovskij Mikhail Vladimirovich

Remizov Pavel Pavlovich

Sobolev Mikhail Sergeevich

Pokrovskaja Tat'Jana Grigor'Evna

Korokin Mikhail Viktorovich

Kochkarov Vladimir Iskhakovich

Arustamova Anna Aleksandrovna

Vanjan Aleksandr Shotaevich

Protsenko Roman Viktorovich

Avtina Tat'Jana Valer'Evna

Zatolokina Marija Alekseevna

Dates

2015-02-10Published

2013-09-23Filed