FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, and more specifically to a method of producing heterocyclic compounds of the isoquinolinone series, which can be of interest as biologically active substances or semi-products for synthesis thereof. Method of producing furo[3,2-c]isoquinoline-5(4H)-one derivatives of general formula I, where R=tert-butyl, 1-adamantyl; R'=phenyl, substituted phenyl, involves reaction at room temperature of 2-imino-1H-indene-1,3(2H)-diones with 1-alkynes in a medium of chlorinated solvents in presence of 100–300 mol% trifluoroacetic acid for 1–3 hours.
EFFECT: efficient method of producing furo[3,2-c]isoquinoline-5(4H)-one derivatives using commercially available compounds which enable to vary the substituent in position 2 of the furan ring.
5 cl, 1 tbl, 8 ex
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