COMPOSITIONS FOR PULMONARY DELIVERY OF LONG-ACTING MUSCARINIC RECEPTOR ANTAGONISTS AND LONG-ACTING B2-ADRENERGIC RECEPTOR AGONISTS AND METHODS AND SYSTEMS ASSOCIATED THEREWITH Russian patent published in 2020 - IPC A61K9/12 A61K9/72 A61K31/4015 A61K31/137 A61P11/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions refers to medicine and pharmacy. Disclosed are: pharmaceutical composition delivered from an inhaler with a measured dose, containing: a suspension medium with a propellant, a plurality of active substance particles comprising a glycopyrrolate or a salt thereof and/or formoterol or a salt thereof, one or more types of respirable suspending particles, each of which is soluble in suspension medium in amount of less than approximately one part per 100 parts of suspension medium, and perforated microstructures, where the total weight of the suspending particles is greater than the total weight of the particles of the active substance, and a method of treating a pulmonary disease or disorder comprising administering the above composition from an inhaler with a measured dose.

EFFECT: technical result is providing physical and chemical stability of composition and uniformity of dose delivered by cosuspensions throughout devastation of capacity of inhaler.

26 cl, 30 dwg, 14 tbl