FIELD: chemistry.
SUBSTANCE: invention relates to novel biologically active ferrocenylalkyl derivatives of C, C'-dipyrazolylselenides of general formula (I), where R is H or CH3 or C6H5, R1 is CH3, CF3, C6H5, R2 is CH3, CF3, C6H5. Invention also relates to versions of the method for production thereof. First version of method involves interaction α-hydroxyalkylferrocene, selected from ferrocenylmethanol, ferrocenylethanol, ferrocenylphenylmethanol with dipyrazolylselenide in a two-phase system containing a water-immiscible organic solvent, selected from CH2Cl2, C2H4Cl2, CHCl3, CCl4, benzene, and an aqueous solution of concentrated acid selected from HBF4, HClO4. Second version of the method envisages interaction of ferrocenylalkylpyrazole with selenium dioxide in pyridine solution during boiling. Desired product is subjected to chromatographic purification on silica gel using both versions of the method using methylene chloride as the eluent.
(I).
EFFECT: invention provides wider range of biologically active substances with high adaptogenic and protective activity.
3 cl, 6 tbl, 25 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING FERROCENYLALKYL DERIVATIVES OF C,C'-DIPYRAZOLYLSELENIDE | 2019 |
|
RU2732409C1 |
| N-PHOSPHORYLATED DERIVATIVES OF 3-β- PHENYLISOPROPYLSYDNONEIMINE SHOWING ANTITUMOR ACTIVITY | 1991 |
|
RU2036914C1 |
| METHOD OF PRODUCING (E)-4-(6,7-DIMETHOXY-2-METHYL-3-QUINOLYL)-3-BUTEN-2-ONE DERIVATIVES | 2010 |
|
RU2425034C1 |
| METHOD FOR PREPARING CONJUGATE OF (6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-YL)ACETALDEHYDE AND 20-HYDROXYECDYSONE AND USING IT AS ANTIOXIDANT AGENT INHIBITING LIPID PEROXIDATION PROCESS | 2010 |
|
RU2490267C2 |
| METHOD OF PREPARING CURATIVE-PROPHYLACTIC AGENT FROM JERUSALEM ARTICHOKE SHOWING ANTISTRESS, ADAPTOGENIC, IMMUNOSTIMULATING, ANTITOXIC, MEMBRANE-STABILIZING AND ANTIOXIDANT SPECIES OF BIOLOGICAL ACTIVITY | 1993 |
|
RU2105563C1 |
| 1-(1,1,1,3,3,3-HEXAFLUORO-2-FERROCENYLPROP-2-YL)-IMIDAZOLE, POSSESSING ANTITUMOUR ACTIVITY AND METHODS OF OBTAINING THEREOF (VERSIONS) | 2013 |
|
RU2533823C1 |
| NOVEL OPTICALLY ACTIVE 4-HYDROXY-2-AZA-9,10-ANTHRAQUINONES, HAVING ANTIINFLAMMATORY ACTIVITY, AND SYNTHESIS METHOD THEREOF | 2010 |
|
RU2436775C1 |
| METHOD FOR PRODUCTION OF BIOACTIVE SUBSTANCE SELENOPYRAN, SELENOPYRAN AND PRODUCTS CONTAINING THE SAME | 2004 |
|
RU2281007C2 |
| IMPROVEMENT OF FOOD STUFF BIOLOGICAL VALUE | 2004 |
|
RU2266683C1 |
| METHOD OF OBTAINING SPECIFIC IMMUNOMODULATOR | 2011 |
|
RU2478399C2 |
