METHOD OF PRODUCING FERROCENYLALKYL DERIVATIVES OF C,C'-DIPYRAZOLYLSELENIDE Russian patent published in 2020 - IPC C07F17/02 A61K31/295 A61P43/00 

Abstract RU 2732409 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing ferrocenylalkyl derivatives of C, C'-dipyrazolylselenide of the following general formula, where R1 = CH3, CF3, C6H5; R2 = CH3, CF3, C6H5. Method involves reaction of iodomethylate of N,N-dimethylaminomethylferrocene with corresponding dipyrazolylselenide in a liquid medium which contains water or dimethylformamide or dimethylsulphoxide as a solvent. Reaction is carried out in the presence of an alkali metal hydroxide or carbonate, the reaction product is separated, dissolved in methylene chloride, washed with a sodium chloride solution, evaporated and subjected to chromatographic purification on silica gel using dichloromethane as eluent.

EFFECT: ferrocenylalkyl derivatives C,C'-dipirazolylselenide obtained according to the method have adaptogenic and protective activity.

1 cl, 5 tbl, 24 ex

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RU 2 732 409 C1

Authors

Babin Valerij Nikolaevich

Belousov Yurij Anatolevich

Volkova Natalya Aleksandrovna

Zinoveva Nataliya Anatolevna

Moshkutelo Ivan Irinarkhovich

Rodionov Aleksej Nikolaevich

Simenel Aleksandr Aleksandrovich

Dates

2020-09-16Published

2019-10-15Filed