DERIVATIVES USED FOR TREATING MUSCULAR ATROPHY Russian patent published in 2020 - IPC C07C251/48 C07D237/20 C07D241/20 A61K31/165 A61K31/192 A61K31/216 A61K31/4406 A61K31/495 A61K31/50 A61P21/00 A61P21/06 

Abstract RU 2715553 C2

FIELD: medicine.

SUBSTANCE: invention relates to use of a derivative of general formula I

,

where R1 and R2 independently of each other represent hydrogen, n is integer between 1 and 2, R3 is a -OH group or -O(C1-C6 alkyl), R4 is C1-C6 alkyl group, R5 and R6 independently represent a halogen atom or a pharmaceutically acceptable salt thereof as a therapeutic agent for treating and/or preventing muscular atrophy in mammals, and/or to limit muscular atrophy in mammals, and/or to stimulate muscle growth in training mammals seeking to increase muscle mass and quality, preventing symptoms of sarcopenia related to age or rehabilitation after loss of muscles, age-related muscular atrophy and/or consequences of drug treatment, and/or immobilisation, and/or cachexia.

EFFECT: disclosed are derivatives used for treating muscular atrophy.

12 cl, 1 dwg, 3 tbl

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RU 2 715 553 C2

Authors

Rejnal, Sofi, N.

Kergoat, Mishlin, R.

Ote, Valeri

Sharon, Kristin, Zh.

Dyuran, Zhan-Deni

Lepifr, Frank, F.

Ode, Annik, M.

Dates

2020-03-02Published

2016-04-14Filed