NOVEL OXIME DERIVATIVES OF 3,5-SECO-4-NOR-CHOLESTANE, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2014 - IPC C07C401/00 A61K31/15 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to oxime derivatives of 3,5-seco-4-nor-cholestane of formula (I) use thereof as medicinal agents, having cytoprotective, specifically neuroprotective, cardioprotective and/or hepatoprotective action, as well as pharmaceutical compositions based thereon. In formula (I) R₁ is -CH₃, R₂ is C₁-C₈ alkyl group, optionally substituted with 1-4 substitutes selected from a halogen atom, a hydroxyl group or a group of formula R^c-Q-(CH₂)_n- (A), in which (i) n is an integer which can assume any value from 1 to 4; and (ii) Q is an oxygen atom or a -NR^a group, in which R^a is selected from a hydrogen atom or a C₁-C₆ alkyl group, and R^c is a hydrogen atom or a group of one of the formulae (C) or (D) or (iii) Q is a -O-C(O)- group or a -NR^a-C(O)- group, in which R^a is as defined earlier, and R^c is a hydrogen atom or C₁-C₆ alkyl, aryl, heteroaryl group, heterocycle, R₃ is a hydrogen atom; R₄ is a hydrogen atom; R₅ is a hydrogen atom or hydroxylamino group (-NH₂-OH); or R₄ and R₅ togethr form an additional carbon-carbon bond between carbon atoms to which they are bonded; R₆ is a hydrogen atom; R₇ is a group selected from (G1, G2, G3, G4, G5 or G6) optionally substituted with a halogen atom or hydroxyl group.

EFFECT: improved properties of compounds.

22 cl, 2 ex