SUBSTITUTED TRIA-AZOLES AND METHODS RELATING THERETO Russian patent published in 2020 - IPC C07D401/12 C07D403/04 C07D405/04 C07D249/04 A61K31/4192 A61K31/422 A61K31/497 A61K31/5377 A61P25/08 A61P25/14 

FIELD: chemistry; medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound having structure (A), or a pharmaceutically acceptable salt thereof, where (i): R₁ is H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl; R₂ is C_1-4-alkyl, -C(=O)-C_1-6-alkanediyl-NH₂ or -C(=O)R₆, where said C_1-6-alkanediyl is optionally substituted with a group selected from phenyl, -OH and -OC_1-4-alkyl; R₃ in each case is Cl, F or trifluoromethyl; R₆ is C_2-4-alkyl, morpholinyl or pyridinyl; and n is equal to 0-2; or (ii): R₁ and R₂, taken together with N, to which they are bonded, form 5-6-member non-aromatic heterocycle, where 5-6-member non-aromatic heterocycle can be substituted with 0-3 R₄; R₃ in each case is Cl, F or trifluoromethyl; in each case R₄ is C_1-4-alkyl; and n is 1 or 2. Invention also relates to a pharmaceutical composition for treating a neurological condition based on said compound.

(A).

EFFECT: novel compounds and a pharmaceutical composition based thereon, which can be used in medicine for treating various neurological disorders selected from essential tremor, epilepsy, status epilepticus or effect of a nerve agent.

34 cl, 4 tbl, 29 ex