FIELD: biochemistry.
SUBSTANCE: invention refers to using a substance containing the H1foo gene, H1foo matrix RNA or H1foo protein to improve the quality of the induced pluripotent stem cell. Also disclosed is a method of producing an induced pluripotent stem cell of improved quality, comprising a step of administering (a) a substance for reprogramming the nucleus and a step of introducing (b) a H1foo gene or a H1foo matrix RNA or H1foo protein into a somatic cell. Invention also relates to use of a composition for producing an induced pluripotent stem cell of improved quality, containing (a) nuclear reprogramming substance and (b) H1foo gene or H1foo matrix RNA or H1foo protein.
EFFECT: invention enables efficient production of induced pluripotent stem cell of improved quality.
8 cl, 5 tbl, 14 dwg
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| RECOMBINANT PLASMID pSN-ZsGreen, CODING SOX2 AND NANOG HUMAN PROTEINS AND FLUORESCENT PROTEIN ZsGreen, DESIGNED TO PRODUCE INDUCED PLURIPOTENT HUMAN STEM CELLS | 2011 |
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| TRANSIENT CELLULAR REPROGRAMMING TO REVERSE CELL AGING | 2019 |
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| METHOD FOR INCREASING RNA EXPRESSION IN CELL | 2018 |
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RU2784654C2 |
